Purification and Kinetics of lignin peroxidase from Emericella nidulans

Abstract

Lignin peroxidase (EC 1.11.1.14) is a potent, heme-containing enzyme that catalyzes oxidative reactions in the presence of hydrogen peroxide. Its wide-ranging capabilities stem from its effectiveness in degrading xenobiotics and various compounds with both phenolic and non-phenolic structures. The enzyme was isolated and purified from Emericella nidulans using ammonium sulfate precipitation, DEAE-cellulose and Sephadex G200. The specific activity was 416.7 units mg-1 protein, and the purification fold was 148.6 from Sephadex G-200. The Km and Vmax values were determined to be 0.93 mM and 93.3 units mg-1 protein, respectively. The enzyme showed optimal activity at 45°C and pH 5.0. It demonstrated thermostability at 60°C, which was further enhanced by the presence of trehalose (a disaccharide) or sorbitol (a polyol). Additionally, the enzyme maintained good storage stability at 25°C. These results indicate that the fungal lignin peroxidase was purified with appreciable specific activity and thermostability. This offers the enzyme the advantage to be applied in decolorization of synthetic dyes.

Authors

1 Botany Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt

2 Botany Department, Faculty of Science, Damietta University, New Damietta 34517 Egypt

3 Botany Department, Faculty of Science, Port-Said University, Port-Said 31111 Egypt

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